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Pharmacological agents for periodontal regeneration: A Review

Nandini T.K, Mahantesha S, Mani R, Kranti K


The diseases of the periodontium are common, affecting up to 90% of the global inhabitants. The mildest form of periodontal disease presents itself as gingivitis, which is reversible and mainly caused by the bacterial biofilm on teeth and adjacent gingiva. Whereas, periodontitis is the moderate to severe form of periodontal disease and results in loss of connective tissue and bone support and is one of the major causes of adult tooth loss. The ultimate goal of periodontal treatment is to prevent further attachment loss and regenerate periodontal supporting tissues. To achieve successful periodontal regeneration, various therapeutic strategies are available. Over the past two decades, a variety of pharmacological agents have also been studied for regeneration of lost periodontal structures. This informational review paper describes the various pharmacological agents which are considered important for promoting periodontal regeneration.


Bisphosphonates; host modulation therapy; periodontal regeneration; pharmacological agents

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