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Vogt-koyanagi-harada disease: A potentially debilitating diagnosis of exclusion

Tungki Pratama Umar, Reynold Siburian

Abstract


Background: Vogt-Koyanagi-Harada (VKH) disease is a systemic autoimmune granulomatous disease that targets melanocyte-rich tissue with potentially visually-threatening outcome for patients. It is manifested in eyes, inner ears, skin, and hair. Aim: This review aims to give a brief information about VKH disease, especially regarding the diagnosis and treatment. Conclusion: VKH disease is a diagnosis of exclusion, a comprehensive history taking and physical examinations are required for prompt treatment using immunosuppressive agent to improve patient outcomes. Clinical Significance: It is possible to treat this condition by applying diagnostic criteria. This requires a very thorough review of possible differential diagnosis and should then be treated with high corticosteroid immunosuppressive drugs. This is solely responsible for stopping the visual impairment and recurrence of the disease.

Keywords


Corticosteroids; Human leukocyte antigen; Immunomodulator; Immunosuppressive agent; Vogt-Koyanagi-Harada disease

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References


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