Open Journal Systems

Cover Image

Stem Cells in Dentistry

Maria Monisha, Tatu Joy, Shashi Kiran

Abstract


Scientific progression in the field of molecular biology has unraveled the regenerative capacity of lost tissue in the human body with stem cells. The regenerative capacity of oral and dental tissues is an emerging trend in the field of dentistry. The property of stem cell is unique where it can be transformed to any form of desirable cell. Many studies and researches are been conducted to unveil the potency of stem cells. Among the various tissues, dental pulp in the tooth is considered a nature gifted stem cell for regeneration and tissue engineering application. Due to the advances in the field of dentistry, we are in the verge of shift from simple procedures for disease management to biological care for diagnosis and treatment. This article aims at briefly reviewing literature obtained about stem cells with emphasis on their properties, method of harvesting, preservation, and their importance in cranial and maxillofacial region. Stem cells derived from tooth have immense dental and medical application. The future dentistry is stem cell based where one’s own cell can be used to cure diseases. The utilization of dental tissue for regeneration in the maxillofacial region is becoming clearer and will lead to significant benefits in the management of dental diseases.

Keywords


Craniofacial defect; dental pulp; scaffolds; stem cells; tooth regeneration

Full Text:

ABSTRACT PDF

References


Gopal SK, Lankupalli MA. Stem cell therapy: A newhope for dentist. J Clin Diag Res 2012;6:142-4.

Becker AJ, McCulloch EA, Till JE. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 1963;197:452-4.

Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981;292:154‑6.

Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965;37:614-36.

Gurdon JB, Byrne JA. The first half-century of nuclear transplantation. Proc Natl Acad Sci U S A 2003;100:8048-52.

Fiegel HC, Lange C, Kneser U, Lambrecht W, Zander AR, Rogiers X, et al. Fetal and adult liver stem cells for liver regeneration and tissue engineering. J Cell Mol Med 2006;10:577-87.

Arthur A, Rychkov G, Shi S, Koblar SA, Gronthos S. Adult human dental pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues. Stem Cells 2008;26:1787-95.

Hutmacher DW, Goh JC, Teoh SH. An introduction to biodegradable materials for tissue engineering applications. Ann Acad Med Singapore 2001;30:183-91.

Tammannavar P. Dental pulp stem cells scope in dentistry: A review. IOSR J Dent Med Sci 2013;8:38-41.

Herberts CA, Kwa MS, Hermsen HP. Risk factors in the development of stem cell therapy. J Transl Med 2011;9:29.

Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A 2000;97:13625-30.

Zhu W, Liang M. Periodontal ligament stem cells: Current status, concerns, and future prospects. Stem Cells Int 2015;2015:972313.

Sedgley CM, Botero TM. Dental stem cells and their sources. Dent Clin North Am 2012;56:549-61.

Tziafas D, Smith AJ, Lesot H. Designing new treatment strategies in vital pulp therapy. J Dent 2000;28:77-92.

Kawaguchi H, Hirachi A, Hasegawa N, Iwata T, Hamaguchi H, Shiba H, et al. Enhancement of periodontal tissue regeneration by transplantation of bone marrow mesenchymal stem cells. J Periodontol 2004;75:1281-7.

d’Aquino R, De Rosa A, Lanza V, Tirino V, Laino L, Graziano A, et al. Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes. Eur Cell Mater 2009;18:75-83.

Alhadlaq A, Tang M, Mao JJ. Engineered adipose tissue from human mesenchymal stem cells maintains predefined shape and dimension: Implications in soft tissue augmentation and reconstruction. Tissue Eng 2005;11:556-66.

Chrcanovic BR, Reher P, Sousa AA, Harris M. Osteoradionecrosis of the jaws a current overview part 1: Physiopathology and risk and predisposing factors. Oral Maxillofac Surg 2010;14:3-16.

Kikuiri T, Kim I, Yamaza T, Akiyama K, Zhang Q, Li Y, et al. Cell-based immunotherapy with mesenchymal stem cells cures bisphosphonate-related osteonecrosis of the jaw-like disease in mice. J Bone Miner Res 2010;25:1668-79.

Handschel J, Naujoks C, Langenbach F, Berr K, Depprich RA, Ommerborn MA, et al. Comparison of ectopic bone formation of embryonic stem cells and cord blood stem cells in vivo. Tissue Eng Part A 2010;16:2475-83.

Lombaert IM, Brunsting JF, Wierenga PK, Faber H, Stokman MA, Kok T, et al. Rescue of salivary gland function after stem cell transplantation in irradiated glands. PLoS One 2008;3:e2063.

Burt RK, Traynor A, Statkute L, Barr WG, Rosa R, Schroeder J, et al. Nonmyeloablative hematopoietic stem cell transplantation for systemic lupus erythematosus. JAMA 2006;295:527-35.

Tyndall A. Cellular therapy of systemic lupus erythematosus. Lupus 2009;18:387-93.

Lendeckel S, Jödicke A, Christophis P, Heidinger K, Wolff J, Fraser JK, et al. Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: Case report. J Craniomaxillofac Surg 2004;32:370-3.

Zhang Q, Nguyen AL, Shi S, Hill C, Wilder-Smith P, Krasieva TB, et al. Three-dimensional spheroid culture of human gingiva-derived mesenchymal stem cells enhances mitigation of chemotherapy induced oral mucositis. Stem Cells Dev 2012;21:937-47.

Sankaranarayanan S, Ramachandran C, Padmanaban J, Manjunath S, Baskar S, Kumar RS, et al. Novel approach in the management of an oral, premalignant lesion-a case report. J Stem Cells Regen Med 2007;3:21.

Studeny M, Marini FC, Dembinski JL, Zompetta C, Cabreira- Hansen M, Bekele BN, et al. Mesenchymal stem cells: Potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents. J Natl Cancer Inst 2004;96:1593-603.


Refbacks

  • There are currently no refbacks.
x
Message